2-Methylimidazole
2-Methylimidazole is an organic compound that is structurally related to imidazole with the chemical formula CH₃C₃H₂N₂H. It is a white or colorless solid that is highly soluble in polar organic solvents and water. It is a precursor to a range of drugs and is a ligand in coordination chemistry.
2-Methylimidazole is used as a raw material for the preparation of nitroimidazole antibiotics, which is useful in combat anaerobic bacterial and parasitic infections. It acts as a ligand in coordination chemistry.
It is also employed as a hardener or accelerator for epoxy resin and auxiliary agent for textile dyes.
Further, it acts as a catalyst for refolding of enhanced colored fluorescent protein. It is also useful as a building block in the synthesis of biologically active compounds. In addition to this, it is used as an active pharmaceutical ingredient intermediate such as metronidazole and dimetridazole.
Physical Properties:
| Melting Point | 142-143 °C lit. |
| Boiling Point | 267-268 °C lit. |
| Density | 1.0500 rough estimate |
| Vapour pressure | |
| Refractive index | 1.4970 estimate |
| Flash Point | 155 °C |
| Solublity | 780g/l |
| Storage temprature | 2-8°C |
| pKa | 14.44±0.10 Predicted |
| Form | Crystalline Powder |
| Colour | White to light yellow |
| PH | 10.5-11.5 |
| Solublity | Soluble in water and ethanol |
- 2-Methylimidazole is used as a raw material for the preparation of nitroimidazole antibiotics, which is useful in combat anaerobic bacterial and parasitic infections. It acts as a ligand in coordination chemistry.
- It is also employed as a hardener or accelerator for epoxy resin and auxiliary agent for textile dyes. Further, it acts as a catalyst for refolding of enhanced colored fluorescent protein.
- It is also useful as a building block in the synthesis of biologically active compounds. In addition to this, it is used as an active pharmaceutical ingredient intermediate such as metronidazole and dimetridazole.
- 2-Methylimidazole is a monomethylated imidazole that can be used as a building block in the preparation of a wide range of biologically active compounds.
- 2-Methylimidazole as well as other imidazoles can be use as catalyst for refolding of enhanced coloured fluorescent protein.
- 2-Methylimidazole has been identified as a byproduct of fermentation and is detected in foods and mainstream and side-str eam tobacco smoke.
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